Our research explores how intracellular oral pathogens, like Fusobacterium nucleatum, Porphyromonas gingivalis, Treponema denticola and Tanerella forsythia invade and persist within host cells and influence critical signaling pathways. These pathogens can alter cellular processes, including inflammation and immune modulation, potentially disrupting normal cellular homeostasis. By investigating these interactions, we aim to shed light on how such disruptions may create conditions that contribute to chronic diseases and cellular transformation, with implications for understanding systemic health impacts.